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Abnormal maturation pathway of keratinocytes in psoriatic skin
Author(s) -
BERNARD B.A.,
ROBINSON SHIRLEY M.,
VANDAELE SYLVIE,
MANSBRIDGE J.N.,
DARMON M.
Publication year - 1985
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1985.tb02332.x
Subject(s) - involucrin , psoriasis , stratum granulosum , epidermis (zoology) , dermis , keratinocyte , biology , basal (medicine) , pathology , immunology , medicine , stratum corneum , anatomy , endocrinology , in vitro , genetics , insulin
SUMMARY We compared the maturation pathway of normal and psoriatic epidermis using three different markers: (I) Involucrin, which is normally detected in the stratum granulosum in normal skin, was detected in all but the basal layer of involved psoriatic skin; (2) an antigen, recognized by the murine monoclonal antibody Ψ3, was present in all but the basal layer of involved psoriatic skin but was absent from uninvolved and normal skin; (3) fibronectin, which normally localizes in the dermis and the epidermal‐dermal junction, was also detected intra‐ and extracellularly in the psoriatic epidermis. These results indicate that the alterations in keratinocyte maturation found in psoriasis do not arise from a truncation of the normal maturation pathway but rather reflect the onset of an abnormal pathway of differentiation characterized by the expression of Ψ3 antigen and fibronectin and the premature appearance of involucrin.