Premium
Skin irritation caused by transdermal drug delivery systems during long‐term (5 days) application
Author(s) -
HURKMANS J.F.G.M.,
BODDÉ H.E.,
DRIEL L.M.J.,
DOORNE H.,
JUNGINGER H.E.
Publication year - 1985
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1985.tb02321.x
Subject(s) - transdermal , irritation , skin irritation , medicine , drug , dermatology , delivery system , sweat , pharmacology , anesthesia , immunology
SUMMARY We have studied the skin irritation produced by the prolonged application of transdermal therapeutic systems. The systems were applied to the skin of the back of male volunteers for 120 hours, and sweat accumulation and bacterial growth were studied. In some cases hydrogel discs were attached to the systems. The results showed that sweat accumulation contributed more to the skin irritation than the bacterial overgrowth. The incorporation of hydrogels in the transdermal delivery system may help to reduce skin irritation by absorbing water.