Premium
Distribution of polyamines in human epidermis
Author(s) -
BAZE P.,
MILANO G.,
VERRANDO P.,
RENEE N.,
ORTONNE J.P.
Publication year - 1985
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1985.tb02311.x
Subject(s) - polyamine , spermidine , spermine , putrescine , epidermis (zoology) , basal (medicine) , chemistry , biochemistry , biophysics , chromatography , microbiology and biotechnology , biology , endocrinology , anatomy , enzyme , insulin
SUMMARY Consecutive sections through the epidermis were cut parallel to its surface, and the polyamine (PA) concentration in each section was measured by liquid chromatography. There was a constant decrease in PA concentration (expressed as nmol/mg DNA) from the deepest layer to the more superficial layers. Putrescine showed the greatest increase (+83%) ( P < 0.02): The elevations of spermidine and spermine levels were less marked, respectively +30% ( P < 0.05) and + 27% (NS). Proliferating cells in the basal layer possess high polyamine levels and as they mature in the superficial layers their polyamine content decreases.