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The ‘metabolic burst’ in polymorphonuclear leukocytes from patients with quiescent psoriasis
Author(s) -
GEERDINK J.P.M.,
TROOST P.W.,
SCHALKWIJK J.,
JOOSTEN L.A.B.,
MIER P.D.
Publication year - 1985
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1985.tb02310.x
Subject(s) - respiratory burst , opsonin , psoriasis , phagocytosis , zymosan , myeloperoxidase , chemiluminescence , hydrogen peroxide , superoxide , granulocyte , immunology , polymorphonuclear leukocyte , chemistry , luminol , neutrophile , peripheral blood , chronic granulomatous disease , reactive oxygen species , medicine , biochemistry , enzyme , inflammation , in vitro , organic chemistry
SUMMARY We report an investigation of peripheral blood polymorphonuclear leukocytes (PMN) from untreated patients with mild, quiescent psoriasis. Four aspects of the ‘metabolic burst’ were measured to illustrate phagocytosis‐related events. These were: myeloperoxidase activity, hydrogen peroxide release, superoxide production and luminol‐amplified chemiluminescence. Our study does not support the concept of an intrinsic abnormality of the PMN in psoriasis, but provides additional evidence for disease activity‐dependent changes in phagocytic behaviour. Possible interactions with certain humoral factors, the so‐called opsonins, are discussed.