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α 1 ‐Microglobulin: a new antigenic component of the epidermo‐dermal junction in normal human skin
Author(s) -
BOUIC P.,
KANITAKIS J.,
SCHMITT D.,
VINCENT C.,
REVILLARD J.P.,
THIVOLET J.
Publication year - 1985
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1985.tb02288.x
Subject(s) - antigen , human skin , beta 2 microglobulin , monoclonal antibody , basement membrane , stain , immunofluorescence , glycoprotein , indirect immunofluorescence , epitope , antibody , pathology , chemistry , biology , microbiology and biotechnology , immunology , medicine , staining , genetics
SUMMARY Monoclonal antibodies to human α 1 ‐microglobulin (α 1 ‐m), a glycoprotein present in most biological fluids, reacted with the basement membrane of the epidermo‐dermal junction and that of eccrine sweat glands in normal human skin. This immunofluorescence was specific in that control antibodies of known well‐defined reactivity did not stain these structures. Therefore, α 1 ‐m seems to be a new antigenic component of the junction and it may be an interesting antigen to study in diseases of this area.