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Antinuclear antibodies in the relatives of patients with systemic sclerosis
Author(s) -
TAKEHARA K.,
MOROI Y.,
ISHIBASHI Y.
Publication year - 1985
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1985.tb02287.x
Subject(s) - anti nuclear antibody , antibody , medicine , immunodiffusion , immunology , autoantibody , pathogenesis , ouchterlony double immunodiffusion , immunofluorescence , indirect immunofluorescence , pathology , antiserum
SUMMARY Antinuclear antibodies were studied by indirect immunofluorescence and double immunodiffusion in 21 patients with systemic sclerosis and 35 of their relatives. When HE p ‐2 cells were used as the substrate, the frequency of antinuclear antibodies in the patients' sera was 100% and that in the relatives was 26%. When rat liver sections were used, the values were 86% and 17%, respectively. Anticentromere antibody was detected in the serum from the mother of one patient whose serum had anti‐Scl‐70 antibody. Antibody to n ‐RNP was positive in the sera from the brother and daughter of another patient whose serum was positive for anti‐ n ‐RNP and anti‐Scl‐70 antibodies. The high frequency of antinuclear antibodies in the sera from the relatives of systemic sclerosis patients suggests that immunological abnormalities play a part in the pathogenesis of this condition.