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Immunological studies on aphthous ulcer and erythema nodosum‐like eruptions in Behcet's disease
Author(s) -
KANEKO F.,
TAKAHASHI Y.,
MURAMATSU Y.,
MIURA Y.
Publication year - 1985
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1985.tb02082.x
Subject(s) - erythema nodosum , behcet's disease , medicine , dermatology , behcet disease , erythema , genital ulcer , disease , immunology , pathology , sexually transmitted disease , syphilis , human immunodeficiency virus (hiv)
SUMMARY Patients with Behcet's disease show an intense delayed hypersensitivity (DH) reaction to a group of streptococcal bacteria. We have attempted to detect deposits of immune complexes and to analyse cytological reactions in the aphthous ulcers and erythema nodosum (EN)‐like eruptions. Deposits of IgM and positive fluorescence of anti‐streptococcal group D serum were found in vessel walls and sites infiltrated by inflammatory cells. Cytological analysis has revealed that the inflammatory infiltrating cells are mainly composed of activated T‐cells and macrophages in association with natural killer cells. These results suggest that DH reactions with antigen‐antibody mediated cytotoxicity may play an important role in causing the lesions of Behcet's disease.