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Ultraviolet radiation‐induced histopathological changes in the skin of the marsupial Monodelphis domestica . I. The effects of acute and chronic exposures and of photoreactivation treatment
Author(s) -
APPLEGATE L.A.,
STUART T.D.,
LEY R.D.
Publication year - 1985
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1985.tb02068.x
Subject(s) - photolyase , monodelphis domestica , marsupial , ultraviolet radiation , ultraviolet , medicine , biology , pathology , dermatology , chemistry , zoology , radiochemistry , materials science , biochemistry , optoelectronics , gene , dna repair
SUMMARY Post‐ultraviolet radiation (UVR) treatment of the South American opossum, Monodelphis domestica with long‐wavelength radiation (320–400nm) suppressed the induction of histopathological alterations in the skin. This study identifies DNA as a primary chromophore involoved in the induction of various photobiological responses of the skin such as hyperplasia and sunburn cell formatoin, and also identified pyrimidine dimers as one responsible DNA lesion. The histology of skin form opossums exposed to multiple doses of UVR showed that pre‐malignant changes had occurred in the skin.