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Human and murine cutaneous graft‐versus‐host diseases. Potential models for the study of immunologically mediated skin diseases
Author(s) -
SAURAT J. H.,
PIGUET P. F.
Publication year - 1984
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1984.tb15607.x
Subject(s) - medicine , host (biology) , library science , dermatology , biology , computer science , ecology
SUMMARY Cutaneous graft‐versus‐host disease in humans can be regarded as a potential model for the study of (i) lymphocytotoxic reactions directed against the epidermis, and (ii) immunologically mediated cutaneous sclerosis. Toxic epidermal necrolysis and lichen planus are closely reproduced in graft‐versus‐host disease; sclerosis of chronic graft‐versus‐host disease cannot be regarded as strictly similar to any type of scleroderma. Sclerosis is the most consistently reproducible feature of cutaneous graft‐versus‐host disease in mouse chimeras; it offers the opportunity to study a dermal sclerosing reaction which may be considered as T cell dependent. Murine graft‐versus‐host disease presently appears debatable for use as a model of T cell dependent injury of the epidermis since stable established epidermal lesions are difficult to reproduce.