Premium
Ultrastructural study of iron deposition in the eccrine sweat glands of patients with iron overload
Author(s) -
FALANGA V.,
ZHENG P.,
LAVKER R. M.
Publication year - 1984
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1984.tb07311.x
Subject(s) - sweat , ultrastructure , eccrine sweat , eccrine sweat gland , pathology , deposition (geology) , sweat gland , medicine , biology , paleontology , sediment
SUMMARY An ultrastructural study of eccrine sweat glands was carried out on three patients with iron overload (two with idiopathic haemochromatosis and one with transfusional haemosiderosis). In all three patients small electron‐dense particles were seen in both eccrine sweat glands and macrophages. They appeared primarily in the clear cells of the eccrine sweat glands as membrane‐bound irregularly shaped bodies, and were shown to contain iron by energy dispersive X‐ray microanalysis. Iron aggregates in and around sweat glands were also seen on light microscopy.