Premium
Indirect immunofluorescence microscopy of lichen planus
Author(s) -
OLSEN R. G.,
DUPLESSIS D. P.,
SCHULZ E. JOY,
CAMISA C.
Publication year - 1984
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1984.tb07306.x
Subject(s) - stratum granulosum , stratum spinosum , immunofluorescence , direct fluorescent antibody , indirect immunofluorescence , pathology , stratum corneum , dermatology , antigen , medicine , lichen , stratum , biology , immunology , antibody , paleontology , botany
SUMMARY Indirect immunofluorescence microscopy using serum and lesional skin revealed a lichen planus specific antigen (LPSA) in 80% of patients with lichen planus. This antigen is found only in the stratum granulosum and stratum spinosum. It was demonstrated in skin lesions in Caucasians and Negroes in South Africa and the U. S. A. but was not found in the skin of normal people or patients with other dermatoses. Indirect immunofluorescence should prove useful in distinguishing atypical forms of lichen planus from other dermatoses.