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Desmoplastic trichoepithelioma: clinicopathological features and immunohistochemical study of the basement membrane proteins, laminin and type IV collagen
Author(s) -
KALLIOINEN M.,
TUOMI ML.,
DAMMERT K.,
AUTIOHARMAINEN H.
Publication year - 1984
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1984.tb06627.x
Subject(s) - basement membrane , laminin , type iv collagen , trichoepithelioma , pathology , immunohistochemistry , malignancy , calcification , staining , biology , extracellular matrix , chemistry , medicine , microbiology and biotechnology , basal cell , basal cell carcinoma
SUMMARY Six desmoplastic trichoepitheliomas (DT) from four patients were studied immunohistochemically, using antibodies to the human P1 fragment of laminin and the 7S domain of type IV collagen. The staining of the basement membrane around the tumour clusters was distinct and continuous in most areas, but there were discontinuities and a granular appearance of the basement membrane in the areas of keratinized cysts and calcification around some unorganized epithelial cell nests. The discontinuities of the basement membranes may be a sign of epithelial degeneration or altered differentiation rather than malignancy.