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DNA flow cytometry of the epidermis of patients with multiple epidermal carcinomas
Author(s) -
FRENTZ GERDA,
MØLLER ULLA
Publication year - 1984
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1984.tb04723.x
Subject(s) - epidermis (zoology) , flow cytometry , dna , pathology , medicine , biology , cancer research , microbiology and biotechnology , genetics , anatomy
Summary We used DNA flow cytometry to determine whether the uninvolved skin of twenty‐four patients with multiple epidermal cancers differed from normal skin with regard to its epidermal cell kinetics. We also studied the relationship between the cell kinetics and the type of cancer, previous exposure to ionizing or UV radiation, previous arsenic intake, skin type and coexisting psoriasis. Both exposed and unexposed skin was studied. In thirteen patients the S and G 2 M fractions of a monoclonal tumour were compared with the values in unexposed and exposed skin. The S and G 2 M fractions increased progressively from unexposed skin to exposed skin to tumor tissue. Patients who had developed both squamous and basal cell carcinoma differed from those who had developed only basal cell carcinoma by having a significantly higher G 2 M fractions in the exposed skin, and significantly higher S and G 2 M fractions in the unexposed skin. Patients exposed to ionizing radiation tended to show higher G 2 M fractions in exposed skin compared with the remaining individuals ( P =0·06). The presence of psoriasis, exposure to UVR or sunlight and previous arsenic ingestion did not appear to affect the results.