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A serum inhibitor of neutrophil chemotaxis associated with hyperglobulinaemia E in a patient with lymphoma, and recurrent skin infection
Author(s) -
EHRLICH A.,
MATTISON T.D.
Publication year - 1984
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1984.tb04709.x
Subject(s) - chemotaxis , immunology , lymphoma , medicine , antibody , immunoglobulin e , receptor
SUMMARY A patient with a strong serum inhibitor of neutrophil chemotaxis, a possible chemotactic factor inactivator and hyperimmunoglobulinaemia E is described. The patient had a persistent chronic dermatitis which appeared to develop following radiation of the central nervous system for an unclassified lymphoma. Other abnormalities included a general increase of serum immunoglobulins, impaired lymphocyte response to mitogens, and a high Epstein‐Barr antibody titre. This case illustrates that an increased IgE level, previously reported in association with a cellular chemotactic defect, may coexist with serum inhibitors of neutrophil chemotaxis.