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Early cellular reactions induced by dinitrochlorobenzene in sensitized human skin
Author(s) -
CARR M.M.,
BOTHAM P.A.,
GAWKRODGER D.J.,
MCVITTIE E.,
ROSS J.A.,
STEWART I.C.,
HUNTER J. A. A.
Publication year - 1984
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1984.tb04697.x
Subject(s) - dermis , medicine , human skin , langerhans cell , contact dermatitis , immunology , pathology , dermatology , chemistry , biology , antigen , allergy , genetics
SUMMARY Serial biopsies during the first 24 hours after dinitrochlorobenzene (DNCB) challenge in fifteen sensitized patients have shown that DNCB associates with Langerhans cells within 1 hour of application, and has reached the dermis around the appendages by 6 hours.