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Immunological aspects of psoriasis. VI. Impairment of isoprenaline and theophylline‐induced inhibition of mitogen responsiveness
Author(s) -
GUILHOU J.J.,
ANDARY MONIQUE,
CLOT J.
Publication year - 1984
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1984.tb04656.x
Subject(s) - psoriasis , isoprenaline , phytohaemagglutinin , theophylline , peripheral blood mononuclear cell , histamine , concanavalin a , medicine , endocrinology , immune system , immunology , mitogen activated protein kinase , pharmacology , chemistry , stimulation , in vitro , biochemistry
SUMMARY Pharmacological abnormalities occur in the psoriatic epidermis, and if similar abnormalities occur in the peripheral blood mononuclear cells they could impair the immune responses in psoriasis. In a paired control study, we have tested the capacity of histamine, isoprenaline and theophylline (10 −5 and 10 −7 M) to inhibit the mitogen responsiveness of blood mononuclear cells from normal and psoriatic subjects, using phytohaemagglutinin and concanavalin A. In the normal controls, mitogen responsiveness was inhibited by all three pharmacological agents by about 30 to 50%. In cells from psoriatic patients, the response in the presence of histamine was inhibited (as in the controls), but isoprenaline caused no inhibition, and theophylline paradoxically increased the mitogenic responses. These results suggest there is a defect in the pharmacological response of the blood mononuclear cells in psoriasis.