Premium
Human skin aryl hydrocarbon hydroxylase
Author(s) -
FINNEN M.J.,
LAWRENCE C.M.,
SHUSTER SAM
Publication year - 1984
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1984.tb04640.x
Subject(s) - psoriasis , human skin , coal tar , dermis , epidermis (zoology) , enzyme , basal (medicine) , chemistry , enzyme assay , dermatology , medicine , endocrinology , biology , biochemistry , anatomy , organic chemistry , coal , genetics , insulin
SUMMARY Aryl hydrocarbon hydroxylase (AHH) activity has been measured in full‐thickness biopsies of human skin from patients with and without psoriasis. Basal levels of enzyme activity varied over a fivefold range and were not related to age, sex or clinical condition. Induction of AHH activity by the application of coal tar resulted in a two‐to fivefold increase in activity above basal levels, which was not related to the presence or absence of psoriasis. Separation of human skin into dermis and epidermis showed that human skin AHH activity is predominantly dermal.