Premium
The treatment of resistant warts with intralesional bleomycin: a controlled clinical trial
Author(s) -
BUNNEY M.H.,
NOLAN M.W.,
BUXTON P.K.,
GOING S.M.,
PRESCOTT R.J.
Publication year - 1984
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1984.tb04044.x
Subject(s) - bleomycin , medicine , plantar warts , saline , placebo , clinical trial , dermatology , surgery , chemotherapy , pathology , alternative medicine
SUMMARY A controlled double‐blind trial was carried out on fifty‐nine matched pairs of hand warts in a group of twenty‐four patients, with proven resistance to treatment, to study the effectiveness of the intralesional injection of 0·1% solution of bleomycin sulphate in normal saline, compared with a normal saline placebo injected into the paired warts in the same patient. We found that 87·5% of patients showed a more favourable response to bleomycin ( P <0·001); 76% of the fifty‐nine warts treated with bleomycin were cured by one to three injections of up to 0·2 ml of solution. Subsequently 75% of thirty‐two patients with resistant hand warts and 66% of fifteen patients with mosaic plantar warts were cured of all their warts. No Patient received more than 4 mg of bleomycin. No toxicity was experienced. Local pain was on the whole well tolerated. This form of treatment for resistant warts is reliable, safe and acceptable to patients.