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Basement membrane components outline the tumour islands in cylindroma
Author(s) -
WEBER L.,
WICK G.,
GEBHART W.,
KRIEG T.,
TIMPL R.
Publication year - 1984
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1984.tb04015.x
Subject(s) - basement membrane , laminin , cylindroma , fibronectin , type iv collagen , pathology , extracellular matrix , staining , connective tissue , chemistry , matrix (chemical analysis) , biology , microbiology and biotechnology , medicine , chromatography
SUMMARY The main histological feature of cylindroma is the deposition of sheaths of a‘hyalinized’ material contiguous to the tumour cell clusters. Although ultrastructural studies of this material have revealed a basement membrane‐like structure, its exact nature has remained unclear. Using immuno‐staining with affinity‐purified antibodies directed against distinct basement membrane components, we have shown that type IV collagen and laminin are major constituents of this zone. In addition, cell culture studies indicated that both proteins are synthesized by the tumour cells. The immunohistological data make it clear that the tumour matrix between the tumour cell islands is composed not only of basement membrane components, but also is composed of other connective tissue constituents, i.e. type I and III collagen and fibronectin.