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Levels of arachidonic acid and its metabolites in the skin in human allergic and irritant contact dermatitis
Author(s) -
BARR R. M.,
BRAIN S.,
CAMP R. D. R.,
CILLIERS J.,
GREAVES M. W.,
MALLET A. I.,
MISCH K.
Publication year - 1984
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1984.tb04012.x
Subject(s) - arachidonic acid , leukotriene b4 , irritant contact dermatitis , contact dermatitis , chemistry , human skin , allergen , allergy , leukotriene , allergic contact dermatitis , lipoxygenase , prostaglandin e2 , arachidonic acid metabolism , dermatology , medicine , immunology , biochemistry , biology , enzyme , inflammation , asthma , endocrinology , genetics
SUMMARY Increased concentrations of arachidonic acid and prostaglandin E 2 , but not 12‐hydroxy‐eicosatetraenoic acid, were found in the skin in human contact dermatitis due to nickel and chromate allergens. Significant levels of neutrophil chemokinetic activity, with similar properties to leukotriene B 4 , were found in a high proportion of exudates from inflamed skin treated with allergen but not in exudates from untreated skin. Neither arachidonic acid nor its metabolites were increased in primary irritant dermatitis due to benzylalkonium chloride.