Premium
Relative potencies of several non‐steroidal anti‐inflammatory drugs against soya bean 15‐lipoxygenase
Author(s) -
VERRANDO P.,
SHROOT B.,
ORTONNE J.P.,
HENSBY C.N.
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb06821.x
Subject(s) - lipoxygenase , soya bean , in vivo , leukotriene b4 , arachidonate 5 lipoxygenase , anti inflammatory , leukotriene , enzyme , in vitro , chemistry , pharmacology , biochemistry , inflammation , medicine , food science , biology , microbiology and biotechnology , immunology , arachidonic acid , asthma
SUMMARY The 15‐lipoxygenase from soya bean has been claimed to represent a rapid assay procedure for drugs and chemical agents that inhibit other lipoxygenase products (Kingston, 1981). Although the exact role of products derived from skin lipoxygenase enzymes is not well established, many of these products, e.g. leukotriene B 4 , have inflammatory characteristics that warrant further examination (Camp, 1982). We have therefore started to evaluate anti‐inflammatory drugs in vitro for their ability to inhibit soya bean 15‐lipoxygenase, before appraising their effects in vivo in animal and human skin.