Premium
Epidermal phospholipase A 2 activity is raised in the uninvolved skin of psoriasis
Author(s) -
FORSTER S.,
ILDERTON E.,
SUMMERLY R.,
YARDLEY H.J.
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb06815.x
Subject(s) - psoriasis , dermatology , medicine , phospholipase a2 , chemistry , enzyme , biochemistry
SUMMARY In uninvolved epidermis from nine psoriatic subjects, the mean phospholipase A 2 activity was significantly greater (P <0·01) than in nine controls. The increased activity of this enzyme could lead to an increase in the concentration of free arachidonic acid which, in turn, could lead to increased concentrations of inflammatory mediators.