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Leukotrienes as mediators of skin inflammation
Author(s) -
FORDHUTCHINSON A.W.,
RACKMAN ANITA
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb06814.x
Subject(s) - guinea pig , vascular permeability , leukotriene , leukotriene b4 , leukotriene d4 , chemistry , arachidonic acid , chemotaxis , frog skin , immunology , histamine , inflammation , biology , endocrinology , biochemistry , enzyme , receptor , organic chemistry , asthma , sodium
Leukotrienes (LTs) derived from the 5‐lipoxygenase pathways of arachidonic acid metabolism, are a new group of biologically active mediators. LTC 4 , LTD 4 and LTE 4 are considered collectively to account for the activity of slow reacting substance of anaphylaxis (SRS‐A). They have potent smooth muscle contracting activity (Drazen et al ., 1980; Holme et al ., 1980) and cause vascular permeability changes in guinea‐pig skin (Peck, Piper & Williams, 1981). LTB 4 has been shown to be a potent chemotactic and chemokinetic agent for polymorphonuclear leucocytes (PMNs) (Ford‐Hutchinson et al ., 1980; Smith, Ford‐Hutchinson & Bray, 1980) and to cause vascular permeability changes in rabbit, rat and guinea‐pig skin (Bray et al ., 1981a). In human skin LTB 4 has been shown to be a chemotactic agent for neutrophils (Bray, Ford‐Hutchinson & Smith, 1981b; Camp et al ., 1982). LTC 4 and LTD 4 have pronounced inflammatory actions in human skin causing weal and flare responses and increases in blood flow at low concentrations (Camp et al ., 1982; Bisgard, Kristensen & Sondergaard, 1982). The present studies were designed to investigate a variety of leukotrienes on permeability responses in rabbit and guinea‐pig skin.