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Hyperplastic transformation: the response of mouse skin to irritation
Author(s) -
MARKS F.,
FÜRSTENBERGER G.,
GANSS M.,
RICHTER H.,
SEEMANN D.
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb06812.x
Subject(s) - skin irritation , irritation , dermatology , medicine , transformation (genetics) , pathology , immunology , biology , genetics , gene
Vertebrate skin fulfils its protective function mainly in two different ways: (1) the epithelium forms an extremely resistant layer of horny structures (scales, hair, etc.) which are permanently replaced by means of cellular proliferation and maturation; (2) skin has a remarkable ability to respond quickly to all kinds at attack from the environment by an acceleration of cellular proliferation in the epidermis (which leads to a closure of wounds or a thickening of the protective layer) and by a stimulation of other defense mechanisms such as the recruitment of white blood cells as a constituent of inflammatory reactions.