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Retinoid concentrations in skin, serum and adipose tissue of patients treated with etretinate *
Author(s) -
ROLLMAN O.,
VAHLQUIST A.
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb04618.x
Subject(s) - etretinate , dermis , epidermis (zoology) , metabolite , endocrinology , adipose tissue , medicine , retinoid , endogeny , drug , dermatology , chemistry , pharmacology , psoriasis , pathology , retinoic acid , biochemistry , anatomy , gene
SUMMARY Synthetic and natural retinoids were analysed in epidermis, dermis, subcutis and serum of twenty‐seven patients treated with etretinate (0·6–1·0 mg/kg/day) for 1–36 months. The concentrations of etretinate (including its major metabolite) in serum and normal‐appearing epidermis were 150–600 ng/ml and 50–350 ng/g, respectively. The serum and epidermal values were significantly correlated (P<0·05). The drug progressively accumulated in the subcutis attaining a maximum value of 15,500 ng/g. After the treatment, etretinate disappeared from the epidermis within i week. By contrast, the drug remained in the subcutis for several months after cessation of treatment. The epidermal composition of endogenous retinoids changed during etretinate therapy as reflected in an increased ratio of 3‐dehydroretinol to all‐ trans retinol.