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The level of phospholipase A 2 activity is raised in the uninvolved epidermis of psoriasis
Author(s) -
Forster S.,
Ilderton E.,
Summerly R.,
Yardley H.J.
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb04585.x
Subject(s) - library science , medicine , art , dermatology , computer science
SUMMARY The activity of phospholipase A 2 was measured in uninvolved psoriatic epidermis and normal epidermis. The mean phospholipase A 2 activity in uninvolved psoriatic epidermis, expressed as nmol fatty acid released per mg protein per h, was raised compared with normal epidermis (7.88±s.e. 1·20 vs 2.18±s.e. 0·38; P<0·01). This observation is, we believe, the first demonstration of an abnormality in the uninvolved untreated psoriatic epidermis which could account for the pathology of the disease.