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Effects of short‐wave ultraviolet radiation (UV‐C) on delayed hypersensitivity in the guinea‐pig
Author(s) -
AUSTAD J.,
MØRK NILSJØRGEN
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb04579.x
Subject(s) - guinea pig , ultraviolet radiation , delayed hypersensitivity , chemistry , irradiation , medicine , dermatology , immunology , endocrinology , radiochemistry , antigen , physics , nuclear physics
SUMMARY Guinea‐pigs, previously sensitized to dinitrochlorobenzene (DNCB), were exposed to varying doses of UV‐C radiation (254 nm) on one of the flanks for a period of 15 days. They were then patch‐tested with DNCB immediately after UV treatment. The responses to DNCB were diminished both in the irradiated and non‐irradiated skin compared with control animals which had not received UV‐C radiation. This effect was dose dependent and could only be demonstrated for a limited period of time. Guinea‐pigs exposed to UV‐C radiation did not show a decreased response to sodium lauryl suphate, which is a potent irritant. The influence of UV‐C on delayed hypersensitivity therefore seems to be an immunological effect.