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Ornithine decarboxylase induction in psoralen‐treated mouse epidermis used as a test of UV‐A sunscreen potency
Author(s) -
FOLSO J.,
GANGE R.W.,
MENDELSON I.R.
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb04574.x
Subject(s) - ornithine decarboxylase , potency , epidermis (zoology) , chemistry , pharmacology , in vitro , biochemistry , medicine , enzyme , anatomy
SUMMARY Inhibition by sunscreens of UV‐A‐induced epidermal ornithine decarboxylase (ODC) activity in 8‐methoxypsoralen‐treated mice was used to examine the UV‐A sunscreen activity of two commercial preparations, Uval® (para‐aminobenzoic acid) and PreSun® (a benzophenone derivative). Both gave significant protection against UV‐A doses of up to 3 J/cm 2 and Uval® was more effective that PreSun® in the UV‐A range. At intermediate doses (5–15 J/cm 2 ) neither Uval® nor PreSun® significantly altered the ODC response to UV‐A. At doses of 20–40 J/cm 2 UV‐A, control and PreSun®‐treated animals showed a decline in ODC activity which histological studies suggested was due to severe epidermal damage. This decline in ODC activity and severe epidermal damage was not seen in Uval® ‐treated animals. Topical zinc oxide was highly effective in preventing induction of ODC by UV‐A irradiation at doses up to 40 J/cm 2 , and was significantly more effective than either PreSun® or Uval®.