Premium
Low dose prednisolone or oestrogen in the treatment of women with late onset or persistent acne vulgaris
Author(s) -
DARLEY C.R.,
MOORE J.W.,
BESSER G.M.,
MUNRO D.D.,
KIRBY J.D.
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb03974.x
Subject(s) - acne , medicine , prednisolone , sex hormone binding globulin , endocrinology , medroxyprogesterone acetate , testosterone (patch) , hormone , medroxyprogesterone , androgen , dermatology
SUMMARY Women with persistent or late onset acne vulgaris were divided into two treatment groups. The first received continuous low dose prednisolone to suppress ACTH‐dependent androgen secretion and the second was treated with cyclical oestrogens with medroxyprogesterone to elevate sex hormone binding globulin (SHBG). In both groups there was a significant improvement in the severity of the acne after 4 months’treatment. Although pre‐existing hormonal abnormalities were corrected, the improvement in the acne did not correlate with the baseline hormone levels. However, suitable oestrogen‐progesterone combinations or low dose prednisolone may be given, alone or in combination, to suppress free circulating androgens in these patients with a high probability of improving their acne.