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Treatment of rosacea with 1% metronidazole cream. A double‐blind study
Author(s) -
NIELSEN P.GAMBORG
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb03972.x
Subject(s) - rosacea , metronidazole , placebo , medicine , erythema , double blind , dermatology , lesion , clinical trial , double blind study , surgery , acne , pathology , antibiotics , alternative medicine , microbiology and biotechnology , biology
SUMMARY Eighty‐one patients with rosacea were treated with either i % metronidazole cream or the cream base as a placebo for two months. The trial was performed double‐blind, and the patients were assessed once each month. The variates studied were: (i) overall clinical assessment, (2) lesion counts, (3) degree of erythema, (4) independent photographic evaluation, and (5) patient's opinion. Four patients dropped out of the trial (one treated with metronidazole, three with placebo). In all the variates, 1% metronidazole cream proved to be significantly more effective than placebo.