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Irritant reactions to dithranol in normal subjects and psoriatic patients
Author(s) -
KINGSTON T.,
MARKS R.
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb03969.x
Subject(s) - dithranol , dermatology , erythema , medicine , psoriasis , irritant contact dermatitis , irritation , skin reaction , contact dermatitis , allergy , immunology
SUMMARY The irritant reaction to dithranol on normal forearm skin of forty psoriatics and forty controls was investigated by skin contact thermometry and ID 50 values were calculated for each skin type (I to IV). We concluded that there is no difference between the irritant effects of dithranol in psoriatics and normal subjects. There was no correlation between irritant dose threshold and minimal erythema dose (MED) to ultraviolet radiation (UVR) but skin type I patients are the most sensitive. The irritant response to dithranol can be partially blocked by prior treatment with indomethacin.