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In vivo removal of the horny layer with formic acid
Author(s) -
LEHMANN P.,
KLIGMAN A.M.
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb03547.x
Subject(s) - stratum corneum , formic acid , in vivo , chemistry , aqueous solution , stripping (fiber) , biophysics , chromatography , biomedical engineering , materials science , medicine , organic chemistry , pathology , biology , composite material , microbiology and biotechnology
SUMMARY An alternative to stripping for removing the horny layer has been devised, Occlusive application of 5–7% aqueous formic acid for 24 h induces a separation of the stratum corneum. The inflammatory response is minor and there is little discomfort. The method is useful for studying the effect of various chemicals and physiological agents on barrier‐free skin in vivo . Additionally, the influence of creams and ointments on wound healing may be accurately assessed.