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Langerhans cells in autosomal dominant ichthyosis vulgaris
Author(s) -
FORD G.P.,
FRIEDMANN P.S.,
ROSS J.
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb03546.x
Subject(s) - ichthyosis vulgaris , ichthyosis , keratin , epidermis (zoology) , biology , staining , pathology , dyskeratosis , dermatology , anatomy , medicine , genetics , hyperkeratosis , filaggrin , atopic dermatitis
SUMMARY Five patients with autosomal dominant ichthyosis vulgaris (ADI) were studied to see whether the abnormal keratinization was associated with disturbances of the appearance or the distribution of epidermal Langerhans cells (LCs). The LCs were identified by ATPase staining and electron microscopy. They were present in normal numbers, were of normal morphology and were in their usual mid‐epidermal position. These observations do not support the hypothesis that LCs are involved directly in the process of keratinization.