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Erythrocyte membrane phosphorylation in untreated and in etretinate‐treated psoriatic patients *
Author(s) -
KUMAR R.,
C.WEISS VIRGINIA,
WEST D.P.,
A.CHIERO LAURA
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb03542.x
Subject(s) - etretinate , phosphorylation , medicine , dermatology , psoriasis , erythrocyte membrane , membrane , chemistry , biochemistry
SUMMARY Levels of phosphorylation were decreased in bands 2 to 2.1, 2.9 to 3 and 4‐5 to 4‐8 of erythrocyte membranes from psoriatic patients compared with control values. In addition, higher than control levels of 32 P were incorporated into a new polypeptide hand (mol. wt. 18‐20,000 daltons) of red cell membranes from patients. Uptake of 32 P by these bands returned towards normal after the patients received oral etretmate treatment. These results suggest there is a gcneralixed plasma membrane defect in psoriasis and that ctretinate may affect the metabolism of red cell membrane proteins.