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Metabolic changes at the margin of the spreading psoriatic lesion
Author(s) -
KERKHOF P.C.M.,
RENNES HELGA,
GROOD RUFI,
BAUER F.W.,
MIER P.D.
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb01076.x
Subject(s) - epidermis (zoology) , lesion , psoriasis , pathology , keratin , phosphatase , alkaline phosphatase , biology , acid phosphatase , anatomy , chemistry , medicine , enzyme , biochemistry , immunology
SUMMARY Keratotome slices were cut across the margins of rapidly‐spreading psoriatic plaques. Each slice was divided into eight sections and in each section we measured the percentage cells in S phase and the levels of glucose‐6‐phosphate dehydrogenase (both related to epidermal proliferation), acid phosphatase (associated with keratinization) and alkaline phosphatase (a marker for dermal capillaries). Disturbances in the epidermis extended only 2 to 4 mm into the ‘uninvolved’ skin, whereas the capillaries were metabolically abnormal for a distance of about 2 cm ahead of the advancing edge of the plaque. This implies that changes in the capillary may precede those in the epidermis during the spread of the psoriatic lesion.