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Topical 8‐methoxypsoralen photochemotherapy of psoriasis: a clinical study
Author(s) -
DANNO K.,
HORIO T.,
OZAKI M.,
IMAMURA S.
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb01051.x
Subject(s) - psoriasis , dermatology , medicine , methoxsalen
SUMMARY Topical psoralen plus UV‐A irradiation (topical PUVA) was re‐evaluated with regard to the timing of UV‐A exposure. Symmetrical lesions of fifteen patients with psoriasis were treated with topical PUVA. One side was exposed to UV‐A 2 h after topical application of 1% 8‐methoxypsoralen (2‐h interval therapy), while the other side was exposed to the same doye of UV‐A within 5 min of the topical application (non‐interval therapy). Both regimens were effective. The non‐interval therapy was preferred in one ease, the 2‐hour interval was preferred in three cases, and there was no clear difference in the other eleven cases. There was less tendency to burning with the non‐interval therapy, and our study suggests that this is a useful regimen in the out‐patient treatment of psoriasis.