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A comparison of the phototumorigenic potential of 8‐MOP and 5‐MOP in hairless albino mice exposed to solar simulated radiation
Author(s) -
YOUNG A.R.,
MAGNUS I.A.,
DAVIES A.C.,
SMITH N.P.
Publication year - 1983
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1983.tb01050.x
Subject(s) - hairless , psoralen , methoxsalen , irradiation , radiation , medicine , toxicology , pharmacology , chemistry , dermatology , biology , biochemistry , psoriasis , dna , physics , nuclear physics , quantum mechanics
SUMMARY Hairless albino mice have been treated with topically applied 8‐methoxypsoralen and 5‐methoxypsoralen at two concentrations and exposed to solar simulated radiation. Both these compounds significantly increased the incidence of cutaneous tumours when compared with controls irradiated after treatment with vehicle. This effect was related to psoralen concentration and at the two concentrations investigated there was no significant difference between the compounds.