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Solar urticaria: treatment with PUVA and mediator inhibitors
Author(s) -
PARRISH J.A.,
JAENICKE K.F.,
MORISON W.L.,
MOMTAZ K.,
SHEA C.
Publication year - 1982
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1982.tb04561.x
Subject(s) - mediator , medicine , dermatology , puva therapy , psoriasis
SUMMARY Several therapeutic regimes for solar urticaria were evaluated. A short course of PUVA therapy produced a marked increase in the minimal dose of radiation required to produce urticaria in the six patients treated. This objective evidence of improvement was supported by the patients' reports of greatly increased tolerance to sun‐exposure. Chlorpheniramine, an antihistamine, produced a slight increase in the minimal dose of radiation necessary to produce urticaria but its effectiveness was limited by side‐effects. Indomethacin, an inhibitor of prostaglandin synthetase, produced no beneficial effect.