Premium
Quantitative electron microscopical analysis of leukocyte infiltration in oral ulcers of Behcet's syndrome
Author(s) -
MÜLLER W.,
LEHNER T.
Publication year - 1982
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1982.tb04556.x
Subject(s) - lesion , pathology , infiltration (hvac) , immune system , medicine , cell type , immune reaction , immunology , cell , biology , materials science , genetics , composite material
SUMMARY A stereological electron microscopical technique was applied to biopsies of oral ulcers from patients with Behçet's syndrome in order to carry out a quantitative analysis of the cellular infiltrate. The results have confirmed the light microscopical qualitative findings of a large number of lymphocytes (67%) but have established that a relatively large proportion of the leukocytes (14%) belong to the monocytc‐macrophage series. The virtual absence of plasma cells during the early stages of ulceration and the presence of a large number of lymphocytes and monocytes argue in favour of a type IV cell‐mediated immune reaction. As the lesion progresses a type III reaction develops and this might be associated with immune complexes found in the serum of patients with Behcet's syndrome.