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Circulating testosterone, sex hormone binding globulin and prolactin in women with late onset or persistent acne vulgaris
Author(s) -
DARLEY C.R.,
KIRBY J.D.,
BESSER G.M.,
MUNRO D.D.,
EDWARDS C.R.W.,
REES L.H.
Publication year - 1982
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1982.tb04553.x
Subject(s) - sex hormone binding globulin , acne , medicine , testosterone (patch) , endocrinology , prolactin , hyperprolactinaemia , hormone , globulin , physiology , androgen , dermatology
SUMMARY Serum testosterone, sex hormone binding globulin (SHBG) and prolactin were measured in thirty‐eight women with acne which persisted or started after the age of 18 years. One or more of these levels were abnormal in 76% of patients. Increased testosterone or low SHBG were present alone or in combination in 60% of patients. This group was presumed to have a raised level of non‐protein bound, metabolically‐available testosterone. Hyperprolactinaemia, which was present in 45% of patients, may be important in view of the reported association with increased adrenal androgens. The hormonal abnormalities may be causally related to the acne and a greater understanding of them may lead to better treatment.