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The dilution of proprietary corticosteroid ointments – an attempt to evaluate relative clinical potencies
Author(s) -
Gibson J.R.,
Darley C.,
Kirsch J.,
Saihan E.M.,
Neild V.S.
Publication year - 1982
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1982.tb04538.x
Subject(s) - corticosteroid , dilution , medicine , pharmacology , chemistry , thermodynamics , physics
SUMMARY Ten subjects were assessed using the vasoconstrictor assay technique in a double‐blind study in order to evaluate the potencies of several diluted and undiluted proprietary corticosteroid ointments. Results showed that clobetasol propionate 0.05% (Dermovate®) ointment at a dilution of one part in ten (clobetasol propionate 0.005%) in white soft paraffin was equipotent with betamethasone valerate 0.1 % (Betnovate®) ointment; and no difference in potency was demonstrated between beclomethasone dipropionate 0.025% (Propaderm®), betamethasone valerate 0.1% (Betnovate®) and clobetasone butyrate 0.05% (Eumovate®).