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Short‐duration (‘minutes’) therapy with dithranol for psoriasis: a new out‐patient regimen
Author(s) -
RUNNE U.,
KUNZE J.
Publication year - 1982
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1982.tb00922.x
Subject(s) - dithranol , psoriasis , medicine , regimen , duration (music) , dermatology , surgery , art , literature
SUMMARY Eighty‐five patients with widespread psoriasis were treated with daily short‐term applications of dithranol and salicylic acid in yellow soft paraffin. Two different schedules were used: (1)‘3‐h’ therapy using increasing dithranol concentrations (0.1, 0.25, 0.5, 1, 2%) for 3 h; (2)‘minutes’ therapy using high dithranol concentrations (1, 2, 3%) for only 10–20 min. In comparison with the standard dithranol therapy, applied for 24 h each day, the‘3‐h’ therapy showed equal efficacy clinically and histologically, and the‘minutes’ therapy was significantly hotter than the standard therapy, reducing the mean clearing time by 6.8 days. Daily short‐term (‘minutes’) therapy combines all the advantages of dithranol with a convenient and readily acceptable mode of application for home use.