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Severe oral lichen planus: treatment with an aromatic retinoid (etretinate)
Author(s) -
HERSLE KJELL,
MOBACKEN HÅKAN,
SLOBERG KENT,
THILANDER HOLGER
Publication year - 1982
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1982.tb00904.x
Subject(s) - etretinate , placebo , medicine , dermatology , retinoid , oral administration , pathology , psoriasis , chemistry , retinoic acid , biochemistry , alternative medicine , gene
SUMMARY A double‐blind study of twenty‐eight patients with severe oral lichen planus treated with etretinate (75 mg daily) or a placebo for 2 months, showed that the oral retinoid had a marked beneficial effect. Nine non‐responders who had received only placebo then entered an open cross‐over study and they responded well to etretinate. Etretinate thus provided effective symptomatic relief for severe oral lichen planus, but side‐effects were common, and six patients stopped treatment because of them.