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Trauma‐induced bullae; the presenting feature of systemic amyloidosis associated with plasma cell dyscrasia
Author(s) -
HOLDEN C.A.,
WESTON M.J.,
MACDONALD D.M.
Publication year - 1982
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1982.tb00532.x
Subject(s) - plasma cell dyscrasia , dyscrasia , medicine , dermatology , pathology , plasma cell , bone marrow , antibody , immunology , immunoglobulin light chain
SUMMARY Two patients who presented with skin fragility and a bullous eruption were found to have amyloid deposits along the epidermal basement membrane. In both cases a basement membrane similar to that observed in pemphigoid was seen on direct immunofluorescence resulting from the non‐specific absorption of immunoglobulins by the amyloid deposits. Evidence of a plasma cell dyscrasia was found in both patients, one of whom developed nephrotic syndrome.