Premium
Inhibition of neutrophil migration by etretinate and its main metabolite
Author(s) -
DUBERTRET L.,
LEBRETON C.,
TOURAINE R.
Publication year - 1982
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1982.tb00528.x
Subject(s) - etretinate , metabolite , pharmacology , retinoid , chemistry , active metabolite , medicine , dermatology , biochemistry , psoriasis , retinoic acid , gene
SUMMARY By using a very sensitive and reproducible skin chamber technique we have shown that the aromatic retinoid etretinate (Ro 10‐9359) and its main metabolite (Ro 10‐1670) significantly inhibit the migration of neutrophils from the blood to tissues when applied into skin chambers (0.1 mg/ml) or when given orally (1 mg/kg/day for 8 days) to normal volunteers. This pharmacological property could be closely linked to the antipsoriatic properties of these drugs.