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Effect of oral 13‐cis‐retinoic acid on serum lipids
Author(s) -
LYONS F.,
LAKER M.F.,
MARSDEN J.R.,
MANUEL R.,
SHUSTER SAM
Publication year - 1982
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1982.tb00411.x
Subject(s) - acne , triglyceride , medicine , retinoic acid , toxicity , endocrinology , cholesterol , thyroid function , drug , retinoid , chemistry , thyroid , pharmacology , biochemistry , dermatology , gene
SUMMARY Serum lipid concentrations were measured in eighteen patients with severe acne before, during and after treatment with 0.8 mg/kg 13‐cis‐retinoic acid for 3 months. Cholesterol and trigtyceride concentrations increased and HDL‐cholesterol concentrations fell significantly during therapy. There were significant abnormalities of liver function and small decreases in indices of thyroid function. These changes had reverted to normal by 1 month after treatment. The data suggest that use of the drug in acne is likely to be limited by its toxicity.