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How does PUVA inhibit delayed cutaneous hypersensitivity?
Author(s) -
MOSS CELIA,
FRIEDMANN P.S.,
SHUSTER SAM
Publication year - 1982
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1982.tb00400.x
Subject(s) - newcastle upon tyne , dermatology , medicine , history , art history
SUMMARY The inhibitory effect of PUVA on delayed cutaneous hypersensitivity to 2,4‐dinitrochloroben‐zene (DNCB) has been analysed by sensitizing and challenging patients with psoriasis on shielded and treated areas of skin, and comparing the results with those for untreated patients. PUVA suppresses both induction and expression of delayed cutaneous hypersensitivity by systemic as well as local actions, but the major effect is local inhibition of induction. The possible contributions of Langerhans cell depletion, impaired lymphocyte reactivity, and reduced cutaneous inflammatory responses are discussed.