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Combined topical use of difluoromethyl ornithine and methylglyoxal bis (guanylhydrazone) in UV‐irradiated mouse skin
Author(s) -
KÄPYAHO K.,
LAUHARANTA J.,
JÄNNE J.
Publication year - 1982
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1982.tb00384.x
Subject(s) - methylglyoxal , medicine , university hospital , dermatology , library science , family medicine , chemistry , biochemistry , enzyme , computer science
SUMMARY Topical application of difluoromethyl ornithine, an irreversible inhibitor of ornithine decar‐boxylase, on UV‐irradiated mouse skin, reduced epidermal putrescine and spermidine contents and greatly enhanced the epidermal uptake of subsequently applied methylglyoxal bis(guanyl‐hydrazone). High epidermal concentrations of methylglyoxal bis (guanylhydrazone) could effectively be lowered by a single application of an ointment containing spermidine. The present results indicate that difluoromethylornithine and methylglyoxal bis (guanylhydrazone) pene trate mammalian skin from topical ointments, and that, in case of a too high (toxic) methylglyoxal bis (guanylhydrazone) concentration, spermidine can be used as a ‘rescuing’ agent.