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Antigenicity of premelanosomes and melanoma cytotoxic activity demonstrated by spleen mononuclear cells of melanoma‐bearing hamster
Author(s) -
TAMAKI A.,
MISHIMA Y.
Publication year - 1982
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1982.tb00381.x
Subject(s) - melanoma , cytotoxic t cell , antigenicity , hamster , peripheral blood mononuclear cell , tyrosinase , cytoplasm , spleen , chemistry , melanin , cancer research , neoplasm , ocular melanoma , biology , immunology , microbiology and biotechnology , pathology , medicine , antigen , in vitro , biochemistry , enzyme
SUMMARY The antigenicity of premelanosomes, which are specific organelles for melanin biosynthesis in the cytoplasm of malignant melanoma cells, has been revealed by the blastogenic responses of lymphocytes from melanoma‐bearing Syrian (golden) hamsters, using the lymphocyte stimula tion assay. The lymphocytes from these hamsters have also been found to exhibit cytotoxic effects on cultured melanoma cells as shown by the microcytotoxic assay technique.