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Linear IgA disease in adults
Author(s) -
LEONARD J.N.,
HAFFENDEN G.P.,
RING N.P.,
McMINN R.M.H.,
SIDGWICK A.,
MOWBRAY J.F.,
UNSWORTH D.J.,
HOLBOROW E.J.,
BLENKINSOPP W.K.,
SWAIN A.F.,
FRY LIONEL
Publication year - 1982
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1982.tb00360.x
Subject(s) - dermatitis herpetiformis , medicine , enteropathy , gastroenterology , dapsone , incidence (geometry) , immunoglobulin a , group a , antibody , immunology , disease , immunoglobulin g , physics , optics
SUMMARY A multi‐centre study is described in which thirty‐five adult patients with papillary IgA dermatitis herpetiformis (DH) were compared with forty‐two patients with linear IgA deposits, of whom thirty‐four had homogeneous‐linear (HL) and eight had granular‐linear (GL) IgA deposits. The three groups were similar with regard to age of onset, presence of circulating immune complexes and auto‐antibodies, incidence of spontaneous remission, histology of lesional skin and response to dapsone. There was a female predominance in the HL group in contrast to the male predominance in the other two. It was not possible to diagnose the HL group clinically. Some patients had a rash typical of DH whilst others resembled pemphigoid. In the majority, however, no specific diagnosis could be made with confidence. The GL group clinically resembled the DH group. The incidence of positive potassium iodide patch tests was greater in the DH group than in the other two. An associated enteropathy was found in 24% of patients in the HL group, 30% of patients in the GL group and 85 % of patients in the DH group. Fifty‐six percent of HL patients had HLA‐B8 compared with 50% in the GL group and 88% in the DH group.